RAF Typhoon FGR4s have conducted a mission with France's air force in a combined operation on an hidden munitions depot in Syrian territory operated by the IS group, per a report from the UK's MoD.
The facility, identified by intelligence, was thought to be housing weapons and explosive materials, the announcement noted, and was located in hills just to the north of the historic site of Palmyra in central Syria.
"Our aircraft utilized Paveway IV guided bombs to hit a series of approach shafts down to the site... preliminary assessments are that the strike was effective," the MoD said.
There was no sign of any civilian impact in the strike late on Saturday and all the aircraft made a safe return, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as Daesh - established jihadist rule over large swathes of Iraq and Syria prior to its 2019 collapse.
"This operation shows the UK's leading role, and determination to operate in unison with our partners, to eradicate any revival of Daesh and their harmful and extremist ideologies in the region," UK Defence Secretary John Healey remarked.
RAF aircraft have performed surveillance missions over Syria to "prevent any attempted resurgence" of Islamic State subsequent to its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank all the members of our armed forces participating in this operation for their expertise and their valour," the Defence Secretary added. "Including them were thousands of British personnel deployed over Christmas and New Year. This mission, to remove dangerous terrorists who threaten our way of life, demonstrates how British military are always on standby, all year round, ensuring Britain's security domestically and powerful internationally."
Last December, the American forces carried out what it described as a "large-scale strike" against IS targets in the country, subsequent to an ambush resulted in the deaths of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations estimates Islamic State still boasts an estimated 5,000 to 7,000 combatants in both countries.